2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141214
    Bromo-PEG5-alcohol 957205-14-0 98.0%
    Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG5-alcohol
  • HY-W011277
    Fmoc-azetidine-3-carboxylic acid 193693-64-0 99.86%
    Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-azetidine-3-carboxylic acid
  • HY-W039178
    Hydroxy-PEG4-(CH2)2-Boc 518044-32-1 99.34%
    Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191). Hydroxy-PEG4-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-(CH2)2-Boc
  • HY-135798
    Tos-PEG2-NH-Boc 192132-77-7
    Tos-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-NH-Boc
  • HY-140696E
    m-PEG-OH (MW 1000) 9004-74-4 98.0%
    m-PEG-OH (MW 1000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger cancer-killing activity than free Paclitaxel. And it accumulates preferentially in tumor tissues and has only limited distribution in healthy organs.
    m-PEG-OH (MW 1000)
  • HY-140307A
    Sulfo DBCO-PEG4-Maleimide TEA
    Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Sulfo DBCO-PEG4-Maleimide (TEA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Sulfo DBCO-PEG4-Maleimide TEA
  • HY-W190961
    FmocNH-PEG3-CH2CH2NH2 hydrochloride 906079-91-2 99.57%
    FmocNH-PEG3-CH2CH2NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    FmocNH-PEG3-CH2CH2NH2 hydrochloride
  • HY-140222
    Amino-PEG2-C2-hydrazide-Boc 2100306-60-1
    Amino-PEG2-C2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-C2-hydrazide-Boc
  • HY-128805
    Tos-PEG3-NH-Boc 206265-94-3 99.66%
    Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tos-PEG3-NH-Boc
  • HY-140498
    Hydroxy-PEG4-CH2COOH 70678-95-4
    Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-CH2COOH
  • HY-42488
    Hydroxy-PEG3-(CH2)2-Boc 186020-66-6
    Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-(CH2)2-Boc
  • HY-141120
    Boc-NH-PEG10-NHS ester 98.0%
    Boc-NH-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG10-NHS ester
  • HY-140319
    DBCO-mPEG (MW 5kDa) 98.41%
    DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 5kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-mPEG (MW 5kDa)
  • HY-133231
    Bis-PEG10-acid 2055023-26-0 ≥98.0%
    Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG10-acid
  • HY-41541
    Tetraethylene glycol monotosylate 77544-60-6
    Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethylene glycol monotosylate
  • HY-130312
    N-(Azido-PEG4)-N-Boc-PEG4-NHS ester 2112731-96-9
    N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG4)-N-Boc-PEG4-NHS ester
  • HY-W017970
    Boc-C2-NH2 15231-41-1 99.78%
    Boc-C2-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C2-NH2
  • HY-130213
    Thiol-PEG4-acid 749247-06-1
    Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-acid
  • HY-140940
    Biotin-PEG4-methyltetrazine 1835759-81-3 99.00%
    Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Biotin-PEG4-methyltetrazine
  • HY-W039168
    Bromo-PEG3-C2-acid 782475-35-8
    Bromo-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG3-C2-acid
PROTAC Linkers Isoform Comparison

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